Annotation Detail
Information
- Associated Genes
- BRAF
- Associated Variants
- BRAF V600E
- Source Database
- MMMP
- Description
- Inhibition of BRAF signaling using either a broad-spectrum Raf inhibitor (Sorafenib) or by selective knockdown of BRAF(V600E) expression by RNA interference in human melanoma cells leads to decreased beta-Trcp expression, stabilization of IkB, decreased IKK activity, inhibition of NFkB transcriptional activity and sensitization of these cells to apoptosis
- MMMP State
- mut V600E
- MMMP Molecule
- BRAF
- MMMP Molecule Alias
- B-Raf
- MMMP Relationship
- sensitivity to
- MMMP Drug
- BRAF V600E siRNA
- MMMP Model
- 3
- MMMP Reference
- Liu J, Oncogene 2007, 26:1954-8
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| BRAF V600E siRNA | Sensitivity | true |