Annotation Detail
Information
- Associated Genes
- ATF2
- Associated Variants
- ATF2 EXPRESSION
- Source Database
- MMMP
- Description
- ATF2 is a transcription factor implicated in melanoma progression and chemoresistance. Expression of a peptide spanning amino acids 50-100 of ATF2 (ATF2(50-100)) reduces ATF2 transcriptional activities while increasing the expression and activity of c-Jun. Growth and metastasis of SW1 and B16F10 mouse melanomas were inhibited by ATF2(50-100) to varying degrees depending on the mode (inducible, constitutive, or adenoviral delivery) of its expression
- MMMP State
- expressed
- MMMP Molecule
- ATF2
- MMMP Relationship
- sensitivity to
- MMMP Drug
- ATF2 peptide (antagonist)
- MMMP Model
- 2
- MMMP Reference
- Bhoumik A, J Clin Invest 2002, 110:643-50
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| ATF2 peptide (antagonist) | Sensitivity | true |