Annotation Detail
Information
- Associated Genes
- RET
- Associated Variants
- RET UNKNOWN
- Source Database
- MMMP
- Description
- RET proto-oncogene encodes a receptor tyrosine kinase whose ligand is glial cell line-derived neurotrophic factor (GDNF): GDNF significantly amplified cell proliferation, migration and invasion in RETp variant, but not in RETwt melanoma cells
- MMMP State
- polymorphism G691S
- MMMP Molecule
- RET
- MMMP Relationship
- sensitivity to
- MMMP Drug
- GDNF inhibition
- MMMP Model
- 3
- MMMP Reference
- Narita N, Oncogene 2009, 28:3058-68
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| GDNF inhibition | Sensitivity | true |