Annotation Detail

Information
Associated Genes
Associated Variants
NM_000041.4(APOE):c.[388=;526=] AND APOE3 ISOFORM
NM_000041.4(APOE):c.[388=;526=] AND APOE3 ISOFORM
Source Database
GWAS Catalog
Description
Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib.
GWAS Strongest risk allele
rs7412-T
GWAS Catalog disease or trait
Lipoprotein phospholipase A2 activity in cardiovascular disease
GWAS Catalog p-Value
8E-78
GWAS Odds ratio OR beta coefficient
17.11
GWAS 95% confidence interval
[15.31-18.91] (nmol/min/ml) decrease
GWAS parent term
Lipid or lipoprotein measurement
URL
http://www.ebi.ac.uk/efo/EFO_0004746
GWAS parent term
Cardiovascular disease
URL
http://www.ebi.ac.uk/efo/EFO_0005672
URL
http://www.ebi.ac.uk/efo/EFO_0001645
Drugs