Annotation Detail
Information
- Associated Genes
- Associated Variants
-
NM_000041.4(APOE):c.[388=;526=] AND APOE3 ISOFORM
NM_000041.4(APOE):c.[388=;526=] AND APOE3 ISOFORM - Source Database
- GWAS Catalog
- Description
- Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib.
- GWAS Strongest risk allele
- rs7412-T
- GWAS Catalog disease or trait
- Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease
- GWAS Catalog p-Value
- 2E-27
- GWAS Odds ratio OR beta coefficient
- 0.04
- GWAS 95% confidence interval
- [-1.5672-1.6472] unit decrease
- GWAS parent term
- Cardiovascular disease
- URL
- http://www.ebi.ac.uk/efo/EFO_0005672
- URL
- http://www.ebi.ac.uk/efo/EFO_0001645
- GWAS parent term
- Cardiovascular measurement
- URL
- http://www.ebi.ac.uk/efo/EFO_0008432
- GWAS parent term
- Response to drug
- URL
- http://www.ebi.ac.uk/efo/EFO_0008395
Drugs