Annotation Detail
Information
- Associated Genes
- IFNGR2
- Associated Variants
-
IL15RA c.*364T>G
(
ENST00000397248.6,
ENST00000397251.7,
ENST00000620345.4,
ENST00000525219.6,
ENST00000379977.8 )
IL4R p.Gln576Arg (p.Q576R) ( ENST00000543915.6, ENST00000170630.6, ENST00000395762.7 )
TGFB1 c.-1347T>C ( ENST00000539627.5, ENST00000604123.5 )
IFNGR2 c.*424C>T ( ENST00000290219.11, ENST00000381995.5, ENST00000405436.5 )
LTA p.Thr60Asn (p.T60N) ( ENST00000454783.5, ENST00000418386.3 )
IL15RA c.*364T>G ( ENST00000379977.8, ENST00000397248.6, ENST00000397251.7, ENST00000525219.6, ENST00000620345.4 )
IL4R p.Gln576Arg (p.Q576R) ( ENST00000170630.6, ENST00000395762.7, ENST00000543915.6 )
TGFB1 c.-1347T>C ( ENST00000539627.5, ENST00000604123.5 )
IFNGR2 c.*424C>T ( ENST00000290219.11, ENST00000381995.5, ENST00000405436.5 )
LTA p.Thr60Asn (p.T60N) ( ENST00000418386.3, ENST00000454783.5 ) - Associated Disease
- Malignant neoplasm of breast
- Source Database
- DisGeNET
- Description
- Multivariate logistic regression found SNPs in genes important for T helper type 1 (Th1) immunity (IFNGR2 rs1059293, IL15RA rs2296135, LTA rs1041981), Th2 immunity (IL4R rs1801275), and T regulatory cell-mediated immunosuppression (TGFB1 rs1800469) associated with breast cancer risk, mainly among AAs.
- Pubmed
- 23996684
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
- Year of publication
- 2013
Drugs