Annotation Detail
Information
- Associated Genes
- MAP2K1
- Associated Variants
-
MAP2K1 MUTATION
MAP2K1 MUTATION
MAP2K1 c.569-13751A>G ( ENST00000692683.1, ENST00000566326.1, ENST00000685763.1, ENST00000693150.1, ENST00000307102.10, ENST00000685172.1, ENST00000689951.1, ENST00000691937.1, ENST00000686347.1, ENST00000691576.1 )
DUSP2 c.*231A>G ( ENST00000288943.5 )
RAF1 c.-26-3589G>C ( ENST00000251849.9, ENST00000442415.7, ENST00000685437.1, ENST00000685653.1, ENST00000687923.1, ENST00000688543.1, ENST00000689226.1, ENST00000689389.1, ENST00000690397.1, ENST00000690460.1, ENST00000691899.1, ENST00000692093.1, ENST00000693312.1 )
MAP2K1 c.569-13751A>G ( ENST00000307102.10, ENST00000566326.1, ENST00000685172.1, ENST00000685763.1, ENST00000686347.1, ENST00000689951.1, ENST00000691576.1, ENST00000691937.1, ENST00000692683.1, ENST00000693150.1 )
DUSP2 c.*231A>G ( ENST00000288943.5 )
RAF1 c.-26-3589G>C ( ENST00000251849.9, ENST00000442415.7, ENST00000685437.1, ENST00000685653.1, ENST00000687923.1, ENST00000688543.1, ENST00000689226.1, ENST00000689389.1, ENST00000690397.1, ENST00000690460.1, ENST00000691899.1, ENST00000692093.1, ENST00000693312.1 ) - Associated Disease
- Malignant tumor of colon
- Source Database
- DisGeNET
- Description
- DUSP2 rs1724120 [hazard rate ratio (HRR) = 0.72, 95%CI = 0.54, 0.96; AA versus GG/GA), MAP3K10 rs112956 (HRR = 1.40, 95% CI = 1.10, 1.76; CT/TT versus CC) and MAP3K11 (HRR = 1.76, 95% CI 1.18, 2.62 TT versus GG/GT) influenced survival after diagnosis with colon cancer; MAP2K1 rs8039880 (HRR = 2.53, 95% CI 1.34, 4.79 GG versus AG/GG) and Raf1 rs11923427 (HRR = 0.59 95% CI = 0.40, 0.86; AA versus TT/TA) were associated with rectal cancer survival.
- Pubmed
- 23027623
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00081432561624091
- Year of publication
- 2012
Drugs