Annotation Detail
Information
- Associated Genes
- MAP2K1
- Associated Variants
-
KRAS p.Gly13Val (p.G13V)
(
ENST00000256078.10,
ENST00000311936.8,
ENST00000556131.2,
ENST00000557334.6,
ENST00000685328.1,
ENST00000686969.1,
ENST00000688940.1,
ENST00000692768.1,
ENST00000693229.1 )
KRAS p.Gly13Ala (p.G13A) ( ENST00000557334.6, ENST00000256078.10, ENST00000688940.1, ENST00000311936.8, ENST00000686969.1, ENST00000685328.1, ENST00000693229.1, ENST00000692768.1, ENST00000556131.2 )
KRAS p.Gly13Asp (p.G13D) ( ENST00000256078.10, ENST00000311936.8, ENST00000556131.2, ENST00000685328.1, ENST00000557334.6, ENST00000686969.1, ENST00000688940.1, ENST00000692768.1, ENST00000693229.1 )
KRAS p.Gly13Val (p.G13V) ( ENST00000256078.10, ENST00000311936.8, ENST00000556131.2, ENST00000686969.1, ENST00000688940.1, ENST00000692768.1, ENST00000693229.1, ENST00000557334.6, ENST00000685328.1 )
KRAS p.Gly13Ala (p.G13A) ( ENST00000256078.10, ENST00000311936.8, ENST00000556131.2, ENST00000557334.6, ENST00000685328.1, ENST00000686969.1, ENST00000688940.1, ENST00000692768.1, ENST00000693229.1 )
KRAS p.Gly13Asp (p.G13D) ( ENST00000556131.2, ENST00000557334.6, ENST00000256078.10, ENST00000311936.8, ENST00000685328.1, ENST00000686969.1, ENST00000688940.1, ENST00000692768.1, ENST00000693229.1 ) - Associated Disease
- Malignant tumor of colon
- Source Database
- DisGeNET
- Description
- We find that in colon cancer cells harboring a KRAS(G13D) mutant allele, knocking down KRAS alone or the RAFs in combination or the RAF effectors, MEK1 and MEK2, together is effective in delaying tumor growth in vivo.
- Pubmed
- 19492075
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00081432561624091
- Year of publication
- 2009
Drugs