Annotation Detail
Information
- Associated Genes
- ERBB2
- Associated Variants
-
FTO c.124-4485A>T
(
ENST00000471389.6,
ENST00000637001.1,
ENST00000637969.1,
ENST00000636218.1,
ENST00000636491.1 )
TGFBR2 c.170-3300G>C ( ENST00000295754.10, ENST00000359013.4, ENST00000714389.1, ENST00000714390.1, ENST00000714391.1 )
FTO c.124-4485A>T ( ENST00000471389.6, ENST00000636218.1, ENST00000636491.1, ENST00000637001.1, ENST00000637969.1 )
TGFBR2 c.170-3300G>C ( ENST00000295754.10, ENST00000359013.4, ENST00000714389.1, ENST00000714390.1, ENST00000714391.1 ) - Associated Disease
- Malignant neoplasm of breast
- Source Database
- DisGeNET
- Description
- Of the four breast cancer subtypes, the associations of rs12493607 (3p24.1/TGFBR2) with HER-2 overexpression in breast cancer (P = 1.09 × 10(-3)) and rs11075995 (16q12.2/FTO) with basal-like breast cancer (P = 1.64 × 10(-4)) were statistically significant.
- Pubmed
- 25007960
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.24
- Year of publication
- 2014
Drugs