Annotation Detail

Information
Associated Genes
ATP2B1
Associated Variants
MYL2 c.402+245T>C ( ENST00000713801.1, ENST00000713803.1, ENST00000548438.1, ENST00000663220.1, ENST00000713831.1, ENST00000713804.1, ENST00000713805.1, ENST00000713800.1, ENST00000713806.1, ENST00000713828.1, ENST00000228841.15, ENST00000713827.1, ENST00000713830.1, ENST00000713829.1, ENST00000713826.1 )
MYL2 c.-146-55982A>C ( ENST00000713826.1, ENST00000713829.1, ENST00000713828.1, ENST00000713800.1, ENST00000713806.1, ENST00000713805.1, ENST00000713831.1, ENST00000713801.1, ENST00000713803.1 )
HECTD4 c.177+1973A>T ( ENST00000377560.9, ENST00000682272.1, ENST00000550722.5 )
OAS3 c.*1398G>A ( ENST00000679493.1, ENST00000228928.12, ENST00000679354.1, ENST00000680044.1, ENST00000681346.1, ENST00000681497.1, ENST00000679483.1 )
ATP2B1 c.-221-10702C>T ( ENST00000551310.2, ENST00000705822.1, ENST00000428670.8, ENST00000359142.8 )
rs2093395
MYL2 c.402+245T>C ( ENST00000228841.15, ENST00000548438.1, ENST00000663220.1, ENST00000713800.1, ENST00000713801.1, ENST00000713803.1, ENST00000713804.1, ENST00000713805.1, ENST00000713806.1, ENST00000713826.1, ENST00000713827.1, ENST00000713828.1, ENST00000713829.1, ENST00000713830.1, ENST00000713831.1 )
MYL2 c.-146-55982A>C ( ENST00000713800.1, ENST00000713801.1, ENST00000713803.1, ENST00000713805.1, ENST00000713806.1, ENST00000713826.1, ENST00000713828.1, ENST00000713829.1, ENST00000713831.1 )
HECTD4 c.177+1973A>T ( ENST00000377560.9, ENST00000550722.5, ENST00000682272.1 )
OAS3 c.*1398G>A ( ENST00000228928.12, ENST00000679354.1, ENST00000679483.1, ENST00000679493.1, ENST00000680044.1, ENST00000681346.1, ENST00000681497.1 )
ATP2B1 c.-221-10702C>T ( ENST00000359142.8, ENST00000428670.8, ENST00000551310.2, ENST00000705822.1 )
rs2093395
Associated Disease
Hypertensive disease
Source Database
DisGeNET
Description
Five gene variants, rs11066280 (C12orf51), rs12229654 and rs3782889 (MYL2), rs2072134 (OAS3), rs2093395 (TREML2), and rs17249754 (ATP2B1), were found to be associated with hypertension mostly in men (P = 4.76 × 10(-14) to 4.46 × 10(-7) in the joint analysis); three SNPs (rs11066280, rs12229654, and rs3782889) remained significant after Bonferroni correction in an independent population.
Pubmed
24142389
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.332996872251452
Year of publication
2013
Drugs