Annotation Detail
Information
- Associated Genes
- PRTN3
- Associated Variants
-
C5 c.*548-8855T>C
(
ENST00000696281.1 )
C5 c.*548-8855T>C ( ENST00000696281.1 ) - Associated Disease
- rheumatoid arthritis
- Source Database
- DisGeNET
- Description
- Stratified analyses indicated that the TRAF1/C5 rs10818488 A allele was significantly associated with RA in Caucasians (OR = 1.29, 95 %CI = 1.14–1.47, P heterogeneity = 0.026), Asians (OR = 0.92, 95 %CI = 0.86–0.99, P heterogeneity = 0.378) and Africans (OR = 1.56, 95 %CI = 1.23–1.98, P heterogeneity = 0.876), also significantly in positive ACPA and positive RF patients versus controls (ORs were 1.20 and 1.25, 95 %CIs were 1.08–1.33 and 1.14–1.37, P values for heterogeneity were 0.215 and 0.133, respectively).
- Pubmed
- 24234752
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00842462955615354
- Year of publication
- 2013
Drugs