Annotation Detail
Information
- Associated Genes
- JAK1
- Associated Variants
-
JAK1 MUTATION
JAK1 MUTATION - Associated Disease
- Primary myelofibrosis
- Source Database
- DisGeNET
- Description
- JAK2 inhibition became a reality with first patients receiving drugs that targeted JAK2 in 2007 and was marked by the first approval in 2011 of Ruxolitinib a JAK 1 and 2-inhibitor to treat myelofibrosis (MF).
- Pubmed
- 25189729
- Section of the abstract supporting the evidence
- ALL_TEXT_2/3
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 2
- Original source reporting the Gene Disease association
- BeFree,GAD
- DisGENET score for the Gene Disease association
- 0.0079913664221677
Drugs