Annotation Detail
Information
- Associated Genes
- NLRP3
- Associated Variants
-
NLRP3 c.*230G>C
(
ENST00000366496.7,
ENST00000348069.7,
ENST00000697350.1,
ENST00000336119.8,
ENST00000391828.8,
ENST00000391827.3 )
NLRP3 c.*230G>C ( ENST00000336119.8, ENST00000348069.7, ENST00000366496.7, ENST00000391827.3, ENST00000391828.8, ENST00000697350.1 ) - Associated Disease
- Human T-cell lymphotropic virus 1 infection
- Source Database
- DisGeNET
- Description
- NLRP3 rs10754558 G/G was associated with protection against HTLV-1 infection (p = 0.012; odds ratio = 0.37). rs10754558 affects NLRP3 mRNA stability; therefore, our results suggest that higher NLRP3 expression may augment first-line defences, leading to the effective protection against HTLV-1 infection.
- Pubmed
- 25411003
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
- Year of publication
- 2014
Drugs