Annotation Detail
Information
- Associated Genes
- HLA-DQB1
- Associated Variants
-
HLA-DQB1 p.Phe41Cys (p.F41C)
(
ENST00000374943.8,
ENST00000399079.7,
ENST00000399082.7,
ENST00000399084.5,
ENST00000434651.7 )
HLA-DQB1 p.Phe41Ser (p.F41S) ( ENST00000374943.8, ENST00000399079.7, ENST00000399082.7, ENST00000399084.5, ENST00000434651.7 )
HLA-DQB1 p.Phe41Tyr (p.F41Y) ( ENST00000374943.8, ENST00000399079.7, ENST00000399082.7, ENST00000399084.5, ENST00000434651.7 )
HLA-DQB1 p.Phe41Cys (p.F41C) ( ENST00000374943.8, ENST00000399079.7, ENST00000399082.7, ENST00000399084.5, ENST00000434651.7 )
HLA-DQB1 p.Phe41Ser (p.F41S) ( ENST00000374943.8, ENST00000399079.7, ENST00000399082.7, ENST00000399084.5, ENST00000434651.7 )
HLA-DQB1 p.Phe41Tyr (p.F41Y) ( ENST00000374943.8, ENST00000399079.7, ENST00000399082.7, ENST00000399084.5, ENST00000434651.7 ) - Associated Disease
- Drug-Induced Liver Injury
- Source Database
- DisGeNET
- Description
- [Class I and II HLA genotypes affect susceptibility to AC-DILI, indicating the importance of the adaptive immune response in pathogenesis. The HLA genotypes identified will be useful in studies of the pathogenesis of AC-DILI but have limited utility as pre]
- Pubmed
- 21570397
- Original source reporting the Gene Disease association
- GAD
- DisGENET score for the Gene Disease association
- 0.242367031978602
- Year of publication
- 2011
Drugs