Annotation Detail

Information
Associated Genes
INS
Associated Variants
INS p.Tyr108Cys (p.Y108C), INS-IGF2 c.187+923A>G ( ENST00000250971.7, ENST00000397270.1, ENST00000381330.5, ENST00000397262.5, ENST00000512523.1 )
INS p.Tyr108Cys (p.Y108C), INS-IGF2 c.187+923A>G ( ENST00000250971.7, ENST00000381330.5, ENST00000397262.5, ENST00000512523.1, ENST00000397270.1 )
Associated Disease
Neonatal diabetes mellitus
Source Database
DisGeNET
Description
Permanent neonatal diabetes in siblings with novel C109Y INS mutation transmitted by an unaffected parent with somatic mosaicism.
Pubmed
24279684
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.0198152566618621
Year of publication
2013
Drugs