Annotation Detail
Information
- Associated Genes
- GCKR
- Associated Variants
-
GCKR c.1423-418T>C
(
ENST00000264717.7 )
GCKR c.1423-418T>C ( ENST00000264717.7 ) - Associated Disease
- Dyslipidemias
- Source Database
- DisGeNET
- Description
- The minor GCKR A-allele of rs780094 is associated with an increased level of fasting serum triacylglycerol (p = 6 x 10(-14)), impaired fasting (p = 0.001) and OGTT-related insulin release (p = 3 x 10(-6)), reduced homeostasis model assessment of insulin resistance (p = 0.0004), WHO-defined dyslipidaemia (p = 6 x 10(-9)) and a modestly decreased risk of type 2 diabetes (p = 0.01).
- Pubmed
- 18008060
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00672003345355102
- Year of publication
- 2008
Drugs