Annotation Detail

Information
Associated Genes
RET
Associated Variants
RET p.Tyr791Phe (p.Y791F) ( ENST00000355710.8, ENST00000615310.5, ENST00000340058.6, ENST00000713926.1 )
RET p.Tyr791Phe (p.Y791F) ( ENST00000615310.5, ENST00000713926.1, ENST00000340058.6, ENST00000355710.8 )
Associated Disease
Medullary carcinoma of thyroid
Source Database
DisGeNET
Description
We previously identified a four-generation family with medullary thyroid cancer (MTC) and a germline p.Y791F RET mutation whose cancer lacked a strong genotype-phenotype correlation.
Pubmed
23723040
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.32
Year of publication
2014
Drugs