Annotation Detail

Information
Associated Genes
FGFR2
Associated Variants
FGFR2 p.Pro253Arg (p.P253R) ( ENST00000369059.5, ENST00000346997.6, ENST00000351936.11, ENST00000356226.8, ENST00000357555.9, ENST00000358487.10, ENST00000360144.7, ENST00000369060.8, ENST00000369061.8, ENST00000457416.7, ENST00000478859.5, ENST00000369056.5, ENST00000613048.4, ENST00000638709.2, ENST00000682550.1, ENST00000682772.1, ENST00000683211.1, ENST00000684153.1 )
FGFR2 p.Pro253Arg (p.P253R) ( ENST00000346997.6, ENST00000351936.11, ENST00000356226.8, ENST00000357555.9, ENST00000358487.10, ENST00000360144.7, ENST00000369056.5, ENST00000369059.5, ENST00000369060.8, ENST00000369061.8, ENST00000457416.7, ENST00000478859.5, ENST00000613048.4, ENST00000638709.2, ENST00000682550.1, ENST00000682772.1, ENST00000683211.1, ENST00000684153.1 )
Associated Disease
Apert syndrome
Source Database
DisGeNET
Description
Most interestingly a case of early-onset papillary carcinoma of the bladder showing a FGFR2 p.Pro253Arg mutation in exon 7 in a patient with Apert Syndrome was reported recently.
Pubmed
24817968
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.454657861092336
Year of publication
2014
Drugs