Annotation Detail
Information
- Associated Genes
- CYP19A1
- Associated Variants
-
CYP19A1 p.Arg264Cys (p.R264C)
(
ENST00000396404.8,
ENST00000559878.5,
ENST00000396402.6 )
CYP1B1 p.Val432= (p.V432=) ( ENST00000490576.2, ENST00000494864.1, ENST00000610745.5, ENST00000614273.1, ENST00000714520.1 )
CYP19A1 p.Arg264Cys (p.R264C) ( ENST00000396402.6, ENST00000396404.8, ENST00000559878.5 )
CYP1B1 p.Leu432Val (p.L432V) ( ENST00000490576.2, ENST00000494864.1, ENST00000610745.5, ENST00000614273.1, ENST00000714520.1 ) - Associated Disease
- Malignant neoplasm of breast
- Source Database
- DisGeNET
- Description
- The results suggest that the CYP19 Arg(264)Cys polymorphism modifies breast cancer risk (OR=1.5, 95% CI=1.1-2.2), especially in association with alcohol consumption (P for interaction=0.04), whereas the CYP1B1 Leu(432)Val polymorphism appears to play no role here.
- Pubmed
- 12618873
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.113930234010038
- Year of publication
- 2003
Drugs