Annotation Detail
Information
- Associated Genes
- XRCC4
- Associated Variants
-
XRCC4 c.894-1G>A
(
ENST00000282268.7,
ENST00000338635.10,
ENST00000396027.9,
ENST00000511817.1 )
XRCC4 p.Ser309= (p.S309=) ( ENST00000282268.7, ENST00000338635.10, ENST00000396027.9, ENST00000511817.1 )
XRCC4 p.Ser309= (p.S309=) ( ENST00000282268.7, ENST00000338635.10, ENST00000396027.9, ENST00000511817.1 )
XRCC4 c.894-1G>A ( ENST00000282268.7, ENST00000338635.10, ENST00000396027.9, ENST00000511817.1 )
XRCC4 p.Ser309= (p.S309=) ( ENST00000282268.7, ENST00000338635.10, ENST00000396027.9, ENST00000511817.1 )
XRCC4 p.Ser309= (p.S309=) ( ENST00000282268.7, ENST00000338635.10, ENST00000396027.9, ENST00000511817.1 ) - Associated Disease
- breast carcinoma
- Source Database
- DisGeNET
- Description
- Genotypes in XRCC4 were associated with BC risk, with ORs of 1.67 (95 % CI 1.01-2.76) for the combined GA/AA of rs1805377 and 1.69 (95 % CI 1.03-2.77) for rs1056503 TG/GG; these associations were no longer statistically significant in multivariable conditional logistic regression models.
- Pubmed
- 24062231
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00271441872080303
- Year of publication
- 2013
Drugs