Annotation Detail
Information
- Associated Genes
- ATR
- Associated Variants
-
ATR MUTATION
ATR MUTATION - Associated Disease
- Triple Negative Breast Neoplasms
- Source Database
- DisGeNET
- Description
- We found that stress hormones induced DNA damage, phosphorylation of ATR, which was accompanied by an up-regulation of the G1 cell kinase inhibitor p21 and a cell cycle halt of TNBCs in the G1 phase. p21 knockdown abrogated G1 arrest by stress hormones.
- Pubmed
- 25880007
- Section of the abstract supporting the evidence
- RESULTS
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 6
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs