Annotation Detail
Information
- Associated Genes
- UGT1A1
- Associated Variants
-
UGT1A6 c.862-3041G>T, UGT1A5 c.868-3041G>T, UGT1A9 c.856-3041G>T, UGT1A7 c.856-3041G>T, UGT1A4 c.868-3041G>T, UGT1A8 c.856-3041G>T, UGT1A10 c.856-3041G>T, UGT1A3 c.868-3041G>T, UGT1A1 c.864+2842G>T
(
ENST00000344644.10,
ENST00000373445.1,
ENST00000373450.5,
ENST00000373426.4,
ENST00000305139.11,
ENST00000373424.5,
ENST00000406651.1,
ENST00000373414.4,
ENST00000354728.5,
ENST00000373409.8,
ENST00000305208.10,
ENST00000360418.4,
ENST00000482026.6 )
UGT1A6 c.862-3041G>T, UGT1A5 c.868-3041G>T, UGT1A9 c.856-3041G>T, UGT1A7 c.856-3041G>T, UGT1A4 c.868-3041G>T, UGT1A8 c.856-3041G>T, UGT1A10 c.856-3041G>T, UGT1A3 c.868-3041G>T, UGT1A1 c.864+2842G>T ( ENST00000344644.10, ENST00000373445.1, ENST00000373450.5, ENST00000373426.4, ENST00000305139.11, ENST00000373424.5, ENST00000406651.1, ENST00000373414.4, ENST00000354728.5, ENST00000373409.8, ENST00000305208.10, ENST00000360418.4, ENST00000482026.6 ) - Associated Disease
- Myocardial Ischemia
- Source Database
- DisGeNET
- Description
- UGT1A1 rs6742078 TT versus GG genotype was associated with 95% increased bilirubin levels (P < 0.001); TT versus GG genotype was associated with odds ratios (ORs) of 1.03 (95% CI, 0.96-1.11; P = 0.73) for IHD and 1.01 (95% CI, 0.92-1.12; P = 0.68) for MI.
- Pubmed
- 22805420
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
- Year of publication
- 2013
Drugs