Annotation Detail
Information
- Associated Genes
- UCN3
- Associated Variants
-
UCN3 MUTATION
UCN3 MUTATION - Associated Disease
- Promyelocytic leukemia
- Source Database
- DisGeNET
- Description
- Taken together, our results define a novel pathway of PML degradation in ccRCC that involves SCP downregulation, revealing contributions of this pathway to ccRCC progression and offering a mechanistic rationale for combination therapies that jointly target PML degradation and mTOR inhibition for ccRCC treatment.
- Pubmed
- 25293974
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 6
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs