Annotation Detail
Information
- Associated Genes
- CHRNA5
- Associated Variants
-
CHRNA3 c.*1114T>C
(
ENST00000326828.6,
ENST00000348639.7 )
COMT c.616-367C>T ( ENST00000361682.11, ENST00000403710.5, ENST00000406520.7, ENST00000407537.5, ENST00000428707.2, ENST00000449653.5, ENST00000676678.1, ENST00000678255.1, ENST00000678769.1, ENST00000678868.1 )
CHRNA3 c.*1114T>C ( ENST00000326828.6, ENST00000348639.7 )
COMT c.616-367C>T ( ENST00000361682.11, ENST00000403710.5, ENST00000406520.7, ENST00000407537.5, ENST00000428707.2, ENST00000449653.5, ENST00000676678.1, ENST00000678255.1, ENST00000678769.1, ENST00000678868.1 ) - Associated Disease
- nicotine dependence
- Source Database
- DisGeNET
- Description
- In pairwise interaction analysis of SNPs from the two loci (COMT SNP-CHRNA5-CHRNA3 SNP), the interaction of intronic COMT SNP, rs9332377, with CHRNA3 3'UTR SNP rs660652 was significantly associated with ND (p = 0.0005), withstanding correction for multiple testing.
- Pubmed
- 21312287
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0196633669216207
- Year of publication
- 2010
Drugs