Annotation Detail
Information
- Associated Genes
- JAK1
- Associated Variants
-
JAK1 MUTATION
JAK1 MUTATION - Associated Disease
- T-cell prolymphocytic leukemia
- Source Database
- DisGeNET
- Description
- These results for the first time provide a portrait of the mutational landscape of T-PLL and implicate deregulation of DNA repair and epigenetic modulators as well as high-frequency mutational activation of the IL2RG-JAK1-JAK3-STAT5B axis in the pathogenesis of T-PLL.
- Pubmed
- 24825865
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 9
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs