Annotation Detail
Information
- Associated Genes
- CD59
- Associated Variants
-
MTHFS c.380-17198G>A, ST20-MTHFS c.308-17198G>A
(
ENST00000479961.1,
ENST00000258874.4,
ENST00000615374.5,
ENST00000559722.2 )
MTHFS c.380-17198G>A, ST20-MTHFS c.308-17198G>A ( ENST00000258874.4, ENST00000559722.2, ENST00000479961.1, ENST00000615374.5 ) - Associated Disease
- Kidney Diseases
- Source Database
- DisGeNET
- Description
- Borderline significant associations of rs6495446 were observed with CKD at study visit 1 (p = 0.024), eGFR at study visits 1 (p = 0.073) and 4 (lower mean eGFR per C allele by 0.6 ml/min/1.73 m2, p = 0.043) and kidney disease progression (hazard ratio 1.13 per each C allele, 95% CI 1.00-1.26, p = 0.041).
- Pubmed
- 18522750
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00271441872080303
- Year of publication
- 2008
Drugs