Annotation Detail
Information
- Associated Genes
- NR3C1
- Associated Variants
-
HTR2A c.-329+609G>A
HTR2A c.-329+609G>A - Associated Disease
- Fatigue
- Source Database
- DisGeNET
- Description
- HTR2A was up-regulated in CFS through allele-specific expression modulated by transcription factors at critical sites in its promoter: an E47 binding site at position -1,438, (created by the A-allele of rs6311 polymorphism), a glucocorticoid receptor (GR) binding site encompassing a CpG at position -1,420, and Sp1 binding at CpG methylation site -1,224.
- Pubmed
- 20941551
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00672003345355102
- Year of publication
- 2011
Drugs