Annotation Detail
Information
- Associated Genes
- AGTR1
- Associated Variants
-
AGTR1 MUTATION
AGTR1 MUTATION - Associated Disease
- Aortic root dilation
- Source Database
- DisGeNET
- Description
- Increased TGF-β signaling and progression of aortic root dilation in Marfan syndrome can be prevented by the antihypertensive drug losartan, a TGF-β antagonists and angiotensin-II type 1 receptor blocker.
- Pubmed
- 24398790
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 3
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs