Annotation Detail
Information
- Associated Genes
- ATF7IP
- Associated Variants
-
BDNF p.Val148Met (p.V148M)
(
ENST00000532997.5,
ENST00000395981.7,
ENST00000356660.9,
ENST00000314915.6,
ENST00000439476.6,
ENST00000530861.5,
ENST00000395983.7,
ENST00000395986.6,
ENST00000525950.5,
ENST00000533246.5,
ENST00000418212.5,
ENST00000525528.1,
ENST00000533131.5,
ENST00000395978.7,
ENST00000438929.5 )
HTR2A p.Ser34= (p.S34=) ( ENST00000542664.4, ENST00000543956.5 )
PPP3CC c.*99G>A ( ENST00000240139.10, ENST00000289963.12, ENST00000397775.7 )
PPP3CC c.*99G>C ( ENST00000240139.10, ENST00000289963.12, ENST00000397775.7 )
BDNF p.Val148Met (p.V148M) ( ENST00000314915.6, ENST00000356660.9, ENST00000395978.7, ENST00000395981.7, ENST00000395983.7, ENST00000395986.6, ENST00000418212.5, ENST00000438929.5, ENST00000439476.6, ENST00000525528.1, ENST00000525950.5, ENST00000530861.5, ENST00000532997.5, ENST00000533131.5, ENST00000533246.5 )
HTR2A p.Ser34= (p.S34=) ( ENST00000542664.4, ENST00000543956.5 )
PPP3CC c.*99G>A ( ENST00000240139.10, ENST00000289963.12, ENST00000397775.7 )
PPP3CC c.*99G>C ( ENST00000240139.10, ENST00000289963.12, ENST00000397775.7 ) - Associated Disease
- Melancholia
- Source Database
- DisGeNET
- Description
- About 62% of patients exhibiting the allelic combination of GG-GG-TT for rs6265, rs7430 and rs6313 of the BDNF, PPP3CC and HTR2A genes, respectively, and without melancholia showed a HAM-D decline under 17 compared to about 34% of the whole study sample.
- Pubmed
- 25769916
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
- Year of publication
- 2015
Drugs