Annotation Detail
Information
- Associated Genes
- ATF7IP
- Associated Variants
-
ATF7IP MUTATION
ATF7IP MUTATION
rs28386840
SLC6A2 c.-182C>T ( ENST00000568943.6, ENST00000219833.13, ENST00000379906.6, ENST00000414754.7 )
SLC5A7 p.Ile89Val (p.I89V) ( ENST00000264047.3, ENST00000409059.5 )
rs28386840
SLC6A2 c.-182C>T ( ENST00000219833.13, ENST00000379906.6, ENST00000414754.7, ENST00000568943.6 )
SLC5A7 p.Ile89Val (p.I89V) ( ENST00000264047.3, ENST00000409059.5 ) - Associated Disease
- Recurrent depression
- Source Database
- DisGeNET
- Description
- MPT analyses show significant associations of the norepinephrine transporter (NET, SLC6A2) -182 T/C (rs2242446) with recurrent depression [odds ratio, OR = 4.15 (1.91-9.02)], NET -3081 A/T (rs28386840) with increase in appetite [OR = 3.58 (1.53-8.39)] and the presynaptic choline transporter (CHT, SLC5A7) Ile89Val (rs1013940) with HAM-D-17 total score {i.e.
- Pubmed
- 18081710
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
- Year of publication
- 2008
Drugs