Annotation Detail
Information
- Associated Genes
- OGG1
- Associated Variants
-
OGG1 MUTATION
OGG1 MUTATION
rs2284659
GPX6 c.242-12G>C ( ENST00000361902.5, ENST00000474923.1 )
GPX6 p.Phe13Leu (p.F13L) ( ENST00000361902.5, ENST00000474923.1 )
rs2284659
GPX6 c.242-12G>C ( ENST00000361902.5, ENST00000474923.1 )
GPX6 p.Phe13Leu (p.F13L) ( ENST00000361902.5, ENST00000474923.1 ) - Associated Disease
- Malignant neoplasm of breast
- Source Database
- DisGeNET
- Description
- The gene-gene interactions demonstrated a significant four-variant interaction among rs406113 (GPX6), rs974334 (GPX6), rs105213 (OGG1) and rs2284659 (SOD3) (p-value = 0.0008) with high-risk genotype combination showing increased risk for breast cancer (OR = 1.75 [95% CI; 1.26-2.44]).
- Pubmed
- 25416100
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0261892415048637
- Year of publication
- 2014
Drugs