Annotation Detail
Information
- Associated Genes
- CXCL8
- Associated Variants
-
TLR1 p.Ser602Ile (p.S602I)
(
ENST00000308979.7,
ENST00000502213.6 )
TLR1 p.Ser602Ile (p.S602I) ( ENST00000308979.7, ENST00000502213.6 ) - Associated Disease
- tuberculosis
- Source Database
- DisGeNET
- Description
- In addition, after stimulated with inactivated lysate of M. tuberculosis strain H37Rv, samples of peripheral blood mononuclear cells (PBMCs) from children with the rs5743618 GT genotypes showed a decreased level of Tumor Necrosis Factor-a (TNF-a) and CXC chemokine ligand 10 (CXCL10) production, invariable production of interleukin-6 (IL-6) and IL-8 and increased production of IL-10 ex vivo.
- Pubmed
- 25544311
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0105301511843394
- Year of publication
- 2014
Drugs