Annotation Detail
Information
- Associated Genes
- CTLA4
- Associated Variants
-
CTLA4 MUTATION
CTLA4 MUTATION - Associated Disease
- Tumor Immunity
- Source Database
- DisGeNET
- Description
- The discovery that antibody blockade of the T cell co-inhibitory receptor cytotoxic T lymphocyte-associated protein 4 (CTLA-4) can restore tumor immunity against many murine transplantable tumors leading to complete rejection of established cancer forever changed the field of immunotherapy.
- Pubmed
- 25555570
- Section of the abstract supporting the evidence
- ALL_TEXT_1/3
- Number of the section of the abstract supporting the evidence
- 1
- Number of the sentence supporting the evidence
- 1
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00217153497664243
Drugs