Annotation Detail
Information
- Associated Genes
- FGFR4
- Associated Variants
-
FGFR4 MUTATION
FGFR4 MUTATION - Associated Disease
- Cancer Cell Growth
- Source Database
- DisGeNET
- Description
- We observed that CAFs secrete more FGF-1/-3 than NFs and PFs and promote cancer cell growth and angiogenesis through the activation of FGFR4, which is followed by the activation of Mek/Erk and the modulation of MMP-7 expression.
- Pubmed
- 26183471
- Section of the abstract supporting the evidence
- ALL_TEXT_2/3
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 6
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs