Annotation Detail
Information
- Associated Genes
- MC4R
- Associated Variants
-
MC4R p.Ile251Leu (p.I251L)
(
ENST00000299766.5 )
MC4R p.Ile251Leu (p.I251L) ( ENST00000299766.5 ) - Associated Disease
- diabetes mellitus
- Source Database
- DisGeNET
- Description
- However, carriers of MC4R (I251L), a rare variant associated with increased weight loss after RYGB and increased basal activity in vitro, were more likely to have early and weight-independent resolution of diabetes than noncarriers, indicating a role for MC4Rs in the effects of RYGB.
- Pubmed
- 23159449
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00399568321108385
- Year of publication
- 2013
Drugs