Annotation Detail

Information
Associated Genes
SRD5A1
Associated Variants
SRD5A2 p.Ala88= (p.A88=) ( ENST00000622030.2 )
SRD5A2 p.Leu89Val (p.L89V) ( ENST00000622030.2 )
Associated Disease
Malignant neoplasm of prostate
Source Database
DisGeNET
Description
Low-activity V89L variant in SRD5A2 is associated with aggressive prostate cancer risk: an explanation for the adverse effects observed in chemoprevention trials using 5-alpha-reductase inhibitors.
Pubmed
17448593
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.0174158870748576
Year of publication
2007
Drugs