Annotation Detail

Information
Associated Genes
PAH
Associated Variants
PAH p.Arg408Trp (p.R408W) ( ENST00000307000.7, ENST00000553106.6 )
PAH p.Ala403Val (p.A403V) ( ENST00000307000.7, ENST00000553106.6 )
PAH p.Arg261Pro (p.R261P) ( ENST00000307000.7, ENST00000553106.6 )
PAH p.Arg261Gln (p.R261Q) ( ENST00000553106.6, ENST00000307000.7 )
PAH p.Arg408Trp (p.R408W) ( ENST00000307000.7, ENST00000553106.6 )
PAH p.Ala403Val (p.A403V) ( ENST00000307000.7, ENST00000553106.6 )
PAH p.Arg261Pro (p.R261P) ( ENST00000307000.7, ENST00000553106.6 )
PAH p.Arg261Gln (p.R261Q) ( ENST00000307000.7, ENST00000553106.6 )
Associated Disease
Classical phenylketonuria
Source Database
DisGeNET
Description
Among 107 families, 58 were classified as classic PKU (54.2%), 28 as mild PKU (25.9%) and 21 as MHP (19.6%).
Pubmed
22513348
Original source reporting the Gene Disease association
UNIPROT
DisGENET score for the Gene Disease association
0.388522903896075
Year of publication
2012
Drugs