Annotation Detail
Information
- Associated Genes
- GSTO1
- Associated Variants
-
GSTO1 p.Ala140Asp (p.A140D)
(
ENST00000369713.10,
ENST00000539281.5,
ENST00000369710.8 )
GSTO1 p.Ala140Asp (p.A140D) ( ENST00000369710.8, ENST00000369713.10, ENST00000539281.5 ) - Associated Disease
- childhood leukemia
- Source Database
- DisGeNET
- Description
- The polymorphism A140D of GSTO1-1 has been not only associated with distinct urinary profile of arsenic metabolites in populations chronically exposed to iAs in drinking water, but also with higher risk of childhood leukemia and lung disease in non-exposed populations, suggesting that GSTO1-1 involvement in other physiologic processes different from toxics metabolism could be more relevant than is thought.
- Pubmed
- 22293942
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
- Year of publication
- 2012
Drugs