Annotation Detail
Information
- Associated Genes
- APOE
- Associated Variants
-
APOC1 c.*459A>G
IL6R c.950-1722C>T ( ENST00000368485.8, ENST00000344086.8 )
LEPR c.2673+1118C>T ( ENST00000349533.11, ENST00000371059.7, ENST00000616738.4, ENST00000371058.1, ENST00000344610.12, ENST00000371060.7 )
APOC1 c.*459A>G
IL6R c.950-1722C>T ( ENST00000344086.8, ENST00000368485.8 )
LEPR c.2673+1118C>T ( ENST00000344610.12, ENST00000349533.11, ENST00000371058.1, ENST00000371059.7, ENST00000371060.7, ENST00000616738.4 ) - Associated Disease
- Coronary heart disease
- Source Database
- DisGeNET
- Description
- SNPs rs6700896 in LEPR (OR, 1.06; 95% CI, 1.02 to 1.09; per minor allele), rs4537545 in IL6R (OR, 0.94; 95% CI, 0.91 to 0.97), and rs4420638 in the APOE-CI-CII cluster (OR, 1.16; 95% CI, 1.12 to 1.21) were all associated with risk of coronary heart disease.
- Pubmed
- 19567438
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.259776800987652
- Year of publication
- 2009
Drugs