Annotation Detail
Information
- Associated Genes
- ACE
- Associated Variants
-
ENSG00000264813 p.Phe555= (p.F555=), ACE p.Phe1129= (p.F1129=)
(
ENST00000290866.10,
ENST00000428043.5,
ENST00000413513.7,
ENST00000290863.10 )
AGT p.Met259Thr (p.M259T) ( ENST00000679957.1, ENST00000681514.1, ENST00000680041.1, ENST00000680783.1, ENST00000681269.1, ENST00000679684.1, ENST00000366667.6 )
ENSG00000264813 p.Phe555= (p.F555=), ACE p.Phe1129= (p.F1129=) ( ENST00000290863.10, ENST00000290866.10, ENST00000413513.7, ENST00000428043.5 )
AGT p.Met259Thr (p.M259T) ( ENST00000366667.6, ENST00000679684.1, ENST00000679957.1, ENST00000680041.1, ENST00000680783.1, ENST00000681269.1, ENST00000681514.1 ) - Associated Disease
- Hypertensive disease
- Source Database
- DisGeNET
- Description
- When the cohort was stratified by sex, ACE rs4362 and AGT rs699 showed significant associations with WMLs in men only (P = 0.01 and P = 0.03, respectively), and remained significant after controlling for hypertension.
- Pubmed
- 24622918
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.44
- Year of publication
- 2015
Drugs