Annotation Detail
Information
- Associated Genes
- LAMC2
- Associated Variants
-
APOE p.Cys130Arg (p.C130R)
(
ENST00000252486.9 )
APOE p.Cys130Arg (p.C130R) ( ENST00000252486.9 ) - Associated Disease
- Presenile dementia
- Source Database
- DisGeNET
- Description
- When adjusted for CSF Aß42, the association of rs429358 with dementia is greatly reduced but remains significant indicating that APOE polymorphism influences disease by additional mechanisms distinct from Aß42 metabolism.
- Pubmed
- 20847432
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00515739556952576
- Year of publication
- 2010
Drugs