Annotation Detail
Information
- Associated Genes
- CDK6
- Associated Variants
-
CD40 c.51+914T>G
(
ENST00000372276.7,
ENST00000372285.8,
ENST00000695671.1 )
CDK6 c.834+642G>C ( ENST00000265734.8, ENST00000424848.3 )
CD40 c.51+914T>G ( ENST00000372276.7, ENST00000372285.8, ENST00000695671.1 )
CDK6 c.834+642G>C ( ENST00000265734.8, ENST00000424848.3 ) - Associated Disease
- rheumatoid arthritis
- Source Database
- DisGeNET
- Description
- The TT and CC/CG genotypes of 2 single-nucleotide polymorphisms, rs4810485 (CD40) and rs42041 (CDK6), respectively, were associated with a higher rate of joint destruction in ACPA-positive RA patients (P=0.003 and P=0.012, respectively), with rs4810485 being significant after Bonferroni correction for multiple testing.
- Pubmed
- 19644859
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.255287959359933
- Year of publication
- 2009
Drugs