Annotation Detail
Information
- Associated Genes
- TLR4
- Associated Variants
-
TNFRSF1A c.39+3505G>A
(
ENST00000162749.7,
ENST00000540022.5,
ENST00000440083.7 )
rs7696175
ENSG00000285082 c.140+3275G>A, TLR4 c.261-385G>A ( ENST00000355622.8, ENST00000394487.5, ENST00000472304.2 )
TNFRSF1A c.39+3505G>A ( ENST00000162749.7, ENST00000440083.7, ENST00000540022.5 )
rs7696175
ENSG00000285082 c.140+3275G>A, TLR4 c.261-385G>A ( ENST00000355622.8, ENST00000394487.5, ENST00000472304.2 ) - Associated Disease
- breast carcinoma
- Source Database
- DisGeNET
- Description
- Overall, TLR1 rs7696175 (HR 1.40, 95% CI 1.03, 1.91; P(adj) = 0.032), TLR4 rs5030728 (HR 1.96, 95% CI 1.30, 2.95; P(adj) = 0.014), and TNFRSF1A rs4149578 (HR 2.71, 95% CI 1.28, 5.76; P(adj) = 0.029) were associated with increased breast cancer mortality.
- Pubmed
- 25332681
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00325730246496364
- Year of publication
- 2015
Drugs