Annotation Detail
Information
- Associated Genes
- CNGB1
- Associated Variants
-
rs7130588
IL6R c.1067-700C>T ( ENST00000344086.8, ENST00000368485.8 )
rs7130588
IL6R c.1067-700C>T ( ENST00000344086.8, ENST00000368485.8 ) - Associated Disease
- asthma
- Source Database
- DisGeNET
- Description
- Two loci were confirmed to associate with asthma risk in the replication cohorts and reached genome-wide significance in the combined analysis of all available studies (n=57,800): rs4129267 (OR 1·09, combined p=2·4×10(-8)) in the interleukin-6 receptor (IL6R) gene and rs7130588 (OR 1·09, p=1·8×10(-8)) on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP).
- Pubmed
- 21907864
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
- Year of publication
- 2011
Drugs