Annotation Detail
Information
- Associated Genes
- CYP2C9
- Associated Variants
-
CYP2C9 p.Arg144Cys (p.R144C)
(
ENST00000461906.1,
ENST00000260682.8 )
CYP2C9 p.Ile359Leu (p.I359L) ( ENST00000260682.8 )
CYP2C8 p.Lys399Arg (p.K399R) ( ENST00000623108.3, ENST00000371270.6, ENST00000535898.5 )
CYP2C8 p.Arg139Lys (p.R139K) ( ENST00000535898.5, ENST00000628935.1, ENST00000623108.3, ENST00000371270.6 )
CYP2C9 p.Arg144Cys (p.R144C) ( ENST00000260682.8, ENST00000461906.1 )
CYP2C9 p.Ile359Leu (p.I359L) ( ENST00000260682.8 )
CYP2C8 p.Lys399Arg (p.K399R) ( ENST00000371270.6, ENST00000535898.5, ENST00000623108.3 )
CYP2C8 p.Arg139Lys (p.R139K) ( ENST00000371270.6, ENST00000535898.5, ENST00000623108.3, ENST00000628935.1 ) - Associated Disease
- Acute gastrointestinal hemorrhage
- Source Database
- DisGeNET
- Description
- Individuals carrying the gene variants CYP2C8*3 (rs11572080; rs10509681), CYP2C9*2 (rs1799853) or CYP2C9*3 (rs1057910) show increased risk of developing acute gastrointestinal bleeding during the use of NSAID that are CYP2C8 or CYP2C9 substrates.
- Pubmed
- 19422321
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000542883744160607
- Year of publication
- 2009
Drugs