Annotation Detail
Information
- Associated Genes
- APOE
- Associated Variants
-
NC_000019.10:g.44905579T>G
NC_000019.10:g.44905579T>G - Associated Disease
- arteriosclerosis
- Source Database
- DisGeNET
- Description
- This association is biologically plausible as SNP rs405509 was shown to modify protein binding and transcriptional activity of the APOE protein in vitro and is in linkage disequilibrium with key known variants defining the e2, e3, and e4 alleles that modify risk of atherosclerosis, Alzheimer's disease risk, and progression to AIDS.
- Pubmed
- 19808960
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.207296000331334
- Year of publication
- 2009
Drugs