Annotation Detail
Information
- Associated Genes
- ICAM1
- Associated Variants
-
ICAM1 MUTATION
ICAM1 MUTATION - Associated Disease
- stomach carcinoma
- Source Database
- DisGeNET
- Description
- The HER-2 positive SGC-7901 secreted more transforming growth factor beta 1 (TGF-β1) and resultantly activated MMP-9 to enhance s-ICAM-1 secretion and further studies showed that phosphatidylinositol-3 kinase (PI3K)/Akt/NF-κB signaling pathway was involved in GC pathogenesis.
- Pubmed
- 25613482
- Section of the abstract supporting the evidence
- ALL_TEXT_2/3
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 8
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00271441872080303
Drugs