Annotation Detail
Information
- Associated Genes
- AGTR1
- Associated Variants
-
AGTR1 MUTATION
AGTR1 MUTATION - Associated Disease
- Congenital muscular dystrophy (disorder)
- Source Database
- DisGeNET
- Description
- Our previous study showed treatment with Losartan, an angiotensin II type I receptor antagonist, improved muscle strength and reduced fibrosis through transforming growth factor beta (TGF-β) and mitogen-activated protein kinases (MAPK) signaling inhibition in the dy(2J)/dy(2J) mouse model of MDC1A.
- Pubmed
- 25766329
- Section of the abstract supporting the evidence
- ALL_TEXT_1/3
- Number of the section of the abstract supporting the evidence
- 1
- Number of the sentence supporting the evidence
- 2
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs