Annotation Detail
Information
- Associated Genes
- IRS1
- Associated Variants
-
IRS1 MUTATION
IRS1 MUTATION - Associated Disease
- prostate carcinoma
- Source Database
- DisGeNET
- Description
- Demonstration that IRS expression can be increased in response to a variety of stressors that may lead to resistance or reduced effect of the therapies indicate that NT157-mediated IRS1/2 downregulation is a novel therapeutic approach for management of advanced prostate cancer.
- Pubmed
- 25267499
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 9
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00135720936040152
Drugs