Annotation Detail
Information
- Associated Genes
- CASP9
- Associated Variants
-
CASP9 MUTATION
CASP9 MUTATION - Associated Disease
- Osteosarcoma of bone
- Source Database
- DisGeNET
- Description
- Our results also showed that CYC1 silencing significantly reduces complex III activity and potentiates TRAIL-induced cytochrome c release and caspase-9 activation in OS cells, suggesting that CYC1 silencing acts via the mitochondria-dependent apoptotic pathway.
- Pubmed
- 25562155
- Section of the abstract supporting the evidence
- RESULTS
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 10
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000542883744160607
Drugs